Custom Peptides
Cayman Chemical MethysergIdemaleate 10mg
A 5-HT1 receptor agonist and 5-HT2 receptor antagonist; binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM); binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors; inhibits 5-HT-induced vasoconstriction in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07); decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs; has antinociceptive activity in mouse models of pain induced by substance P, glutamate, NMDA, AMPA, or kainic acid; reduces zymosan-induced paw edema in rats at 10 mg/kg
Cayman Chemical BeraprostsodIum salt 10mg
Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 UG in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.{8136} Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.{8137,8139}
Cayman Chemical Zearalenon 10mg
A mycotoxin; binds to human ERα and ERβ (IC50s = 9 and 5.8 nM, respectively); induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs; induces hyperestrogenism in pigs from 1.5-5 mg/kg; has been found as a contaminant in wheat, maize, and barley and livestock feeds
Cayman Chemical R-Lnsoprazole 10mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical TyrothrIcIn 10mg
A polypeptide antibiotic mixture produced by B. brevis, composed of tyrocidine and gramicidin with rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica; i.v. use leads to hemolysis and lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively)
Cayman Chemical TaurohyodeoxycholIc ACDod 10mg
A taurine-conjugated form of hyodeoxycholic acid; decreases the size and weight of human gallstones in vitro; prevents hepatotoxicity induced by TCDCA, increasing bile flow as well as biliary acid and phospholipid secretion in rats; reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis
Cayman Chemical ResIbufogenIn 10mg
A cardiac glycoside that inhibits the Na+/K+-ATPase; exhibits cardiotonic, vasopressor, and respiratory stimulating actions in both animal and clinical models
Cayman Chemical BesIfloxacInhydrochlorIde 10mg
An ophthalmologic fluoroquinolone antibiotic; active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 μg/ml); inhibits LPS-stimulated production of the inflammatory cytokines IL-1β, IL-8, IL-6, and IL-1α in human THP-1 monocytes; reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endopthalmitis when administered topically using 2 drops of a 0.6% solution per eye
Cayman Chemical CurcumIn nalog C1 10mg
A synthetic curcuminoid and activator of TFEB; inhibits proliferation of HCT116 cells (GI50 = 4 µM); activates TFEB, inducing nuclear translocation in Neuro2a cells at 1 µM; increases LC3-II levels and promotes autophagic flux in Neuro2a cells at 1 µM; activates TFEB and increases autophagy and lysosome biogenesis in rat brain at 10 and 25 mg/kg, p.o.
Cayman Chemical Z-GUGgulsteron 10mg
A competitive antagonist of farnesoid X receptor (IC50 = 17 µM ) that lowers LDL cholesterol and triglyceride levels in rodents fed a high cholesterol diet; demonstrates antitumor-promoting effects in human multiple myeloma and DU145 human prostate cancer cells
Cayman Chemical PapRIVtrIfluoROCTAte salt 10mg
A quorum-sensing peptide; induces IL-6 and TNF-α production by, and NF-κB translocation in, BV-2 microglia cells from 1-25 µM
Cayman Chemical MecamylamInhydrochlorIde 10mg
A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM)
Cayman Chemical CalycosIn 7-OD-GlucosIde 10mg
An isoflavone glycoside; scavenges 34.5% of generated DPPH radicals compared to a vehicle control in a cell-free assay at 100 μg/ml; inhibits LPS-induced cytotoxicity, ROS production, and cytoskeletal defects in HUVECs at 10 μg/ml; reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 26.8 mg/kg